Blast cells with monoclonal surface immunoglobulin in two cases of acute blast crisis supervening on chronic lymphocytic leukaemia.
نویسندگان
چکیده
Acute blast crisis occurred in two patients with previously well-confirmed chronic lymphocytic leukaemia. The finding by direct immunofluorescence of membrane-bound monoclonal immunoglobulins on the surface of the blast cells showed that they were related to B cells in the same way as the proliferating lymphocytes in most patients with chronic lymphocytic leukaemia. In one patient the surface monoclonal IgM detected on both the lymphocytes and the blast cells had the same rheumatoid antibody activity, supporting the concept that the leukaemic cells found during the acute and chronic phases of the disease originated from the same clone.
منابع مشابه
Chronic myelogenous leukaemia (CML)
Clinics Splenomegaly; chronic phase (lasts about 3 yrs) with maintained cell’s normal activities, followed by accelerated phase(s)(blasts still < 15%), and blast crisis (BC-CML) with blast cells > 30%; blood data: WBC: 100 X 10/l and more during chronic phase, with basophilia; a few blasts; thrombocytosis may be present; low leucocyte alkaline phosphatases; typical acute leukaemia (AL) blood da...
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Clinics and pathology Disease Myeloid malignancies: myelodysplastic syndrome (MDS) in 1/4 of cases, with various FAB diagnoses (refractory anaemia (RA), RA with ringed sideroblasts (RARS), RA with excess of blasts (RAEB), RAEB in transformation (RAEB-t), and chronic myelomonocytic leukemia (CMML)), acute non lymphocytic leukaemia (ANLL) in 60% of cases (M2-ANLL in 1/4 of all cases), blast crisi...
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عنوان ژورنال:
- British medical journal
دوره 4 5883 شماره
صفحات -
تاریخ انتشار 1973